diff --git a/Lib/test/test_unittest/testmock/testpatch.py b/Lib/test/test_unittest/testmock/testpatch.py
index bd85fdcfc472a61..27a0584b892a84d 100644
--- a/Lib/test/test_unittest/testmock/testpatch.py
+++ b/Lib/test/test_unittest/testmock/testpatch.py
@@ -2,6 +2,7 @@
 # E-mail: fuzzyman AT voidspace DOT org DOT uk
 # http://www.voidspace.org.uk/python/mock/
 
+import functools
 import os
 import sys
 from collections import OrderedDict
@@ -1076,6 +1077,30 @@ def class_method(cls, a, b=10, *, c): pass
             self.assertRaises(TypeError, method, 1, 2, 3, c=4)
 
 
+    def test_autospec_partialmethod(self):
+        # autospeccing a functools.partialmethod attribute used to
+        # produce a NonCallableMagicMock (the attribute has no __call__ of
+        # its own), making the mock entirely uncallable. It should behave
+        # like autospeccing any other bound method, with `self` and the
+        # partialmethod's own pre-bound arguments excluded from the
+        # enforced signature.
+        class Foo:
+            def method(self, a, b, c=3):
+                return a, b, c
+            partial_method = functools.partialmethod(method, 1)
+
+        Foo().partial_method(2)
+
+        with patch.object(Foo, 'partial_method', autospec=True) as method:
+            self.assertNotIsInstance(method, NonCallableMagicMock)
+            foo = Foo()
+            foo.partial_method(2)
+            foo.partial_method(2, c=4)
+            self.assertRaises(TypeError, foo.partial_method)
+            self.assertRaises(TypeError, foo.partial_method, 2, 3, 4)
+            self.assertRaises(TypeError, foo.partial_method, 2, foo="lish")
+
+
     def test_autospec_with_new(self):
         patcher = patch('%s.function' % __name__, new=3, autospec=True)
         self.assertRaises(TypeError, patcher.start)
diff --git a/Lib/unittest/mock.py b/Lib/unittest/mock.py
index 49011faaa51eaed..dd5ce20f6fa8da0 100644
--- a/Lib/unittest/mock.py
+++ b/Lib/unittest/mock.py
@@ -37,7 +37,7 @@
 from dataclasses import fields, is_dataclass
 from types import CodeType, ModuleType, MethodType
 from unittest.util import safe_repr
-from functools import wraps, partial
+from functools import partialmethod, wraps, partial
 from threading import RLock
 
 
@@ -107,6 +107,20 @@ def _get_signature_object(func, as_instance, eat_self):
             eat_self = True
         # Use the original decorated method to extract the correct function signature
         func = func.__func__
+    elif isinstance(func, partialmethod):
+        # partialmethod always consumes `self` itself: real access binds it via the
+        # descriptor protocol (instance access resolves `self` before applying before
+        # applying the partialmethod's own bound args). When a mock stands in for the
+        # raw class attribute directly, there is no descriptor rebinding at all, so no
+        # caller ever supplies `self` either. Build the effective signature by dropping
+        # `self` from the wrapped function's signature and applying the partialmethod's
+        # own pre-bound positional / keyword arguments to what remains.
+        inner_sig = inspect.signature(func.func, annotation_format=Format.FORWARDREF)
+        params = list(inner_sig.parameters.values())[1:]
+        stub = lambda *args, **kwargs: None
+        stub.__signature__ = inner_sig.replace(parameters=params)
+        func = partial(stub, *func.args, **func.keywords)
+        eat_self = False
     elif not isinstance(func, FunctionTypes):
         # If we really want to model an instance of the passed type,
         # __call__ should be looked up, not __init__.
@@ -155,6 +169,13 @@ def _callable(obj):
         return True
     if isinstance(obj, (staticmethod, classmethod, MethodType)):
         return _callable(obj.__func__)
+    if isinstance(obj, partialmethod):
+        # partialmethod objects have no __call__ of their own, they are non-data
+        # descriptors that only become callable once resolved via the descriptor
+        # protocol (instance /class attribute access). Judge callability from the
+        # wrapped function instead, so autospeccing a partialmethod attribute doesn't
+        # produce an uncallable mock.
+        return _callable(obj.func)
     if getattr(obj, '__call__', None) is not None:
         return True
     return False
diff --git a/Misc/NEWS.d/next/Library/2026-07-10-11-12-13.gh-issue-153581.a0l3uu.rst b/Misc/NEWS.d/next/Library/2026-07-10-11-12-13.gh-issue-153581.a0l3uu.rst
new file mode 100644
index 000000000000000..e044b67518de850
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2026-07-10-11-12-13.gh-issue-153581.a0l3uu.rst
@@ -0,0 +1,6 @@
+Fix :func:`unittest.mock.create_autospec` (and ``mock.patch(...,
+autospec=True)``) producing a completely uncallable
+:class:`~unittest.mock.NonCallableMagicMock` when the autospecced attribute
+is a :class:`functools.partialmethod`. The mock is now callable and enforces
+the partial method's effective signature (``self`` and the partialmethod's
+own pre-bound arguments excluded).